Innovation Quarter Phase II
Phase II marks a transformative expansion of Winston-Salem’s innovation district—paving the way for up to 2.7 million square feet of mixed-use development, including clinical, lab, office, residential, retail and hospitality facilities, as well as more than 12 acres of publicly accessible green space.
Breaking Ground
Infrastructure milestone achieved in Innovation Quarter expansion
In early 2025 horizontal infrastructure work was completed for the future Innovation Quarter Phase II. This stage included laying of fiber and electrical conduit, site grading, installation of lighting and trees, streetscaping and an almost half-mile extension of the Long Branch Trail.
“This catalytic step marks a major milestone in the continued evolution of Innovation Quarter, setting the stage for accelerated industry growth in the development and manufacturing of patient therapies,” said Jason Kaplan, Associate Vice President of Innovation Quarter Operations. “These infrastructure enhancements will serve as the foundation for a dynamic new chapter in the Winston-Salem region’s innovation ecosystem.”
As part of Phase II infrastructure development, Innovation Quarter facilitated an agreement through infrastructure development partner Wexford Science & Technology and general contractor The Whiting-Turner Contracting Company, ensuring 20% percent participation by MWBE (Minority-/Women-owned Business Enterprise) firms was met by the project’s completion.
Mark Owens
President and CEO of Greater Winston-Salem Inc.
“Phase II of Innovation Quarter’s development represents great potential for growing our economy and workforce, both within the district itself and across greater Winston-Salem and Forsyth County. When companies and talent consider Winston-Salem they are drawn to the vibrant atmosphere of the downtown core and the Innovation Quarter–the mix of creativity and innovation has become a symbol of Winston-Salem’s identity. This is a city where you can find your spot, and we are certain that many will find theirs in iQ’s Phase II.”
Eugene A. Woods
CEO, Advocate Health
“The Innovation Quarter is helping Winston-Salem thrive as a center of progress and possibility. Phase II strengthens Advocate Health’s commitment to this community, expanding an ecosystem of 150 partners and creating opportunities that will transform lives through regenerative medicine and biomedical science. This is innovation with purpose — and Winston-Salem is leading the way.”
Annette Scippio
City Council, East Ward
“The establishment and growth of the Innovation Quarter over the last 20-plus years has been exciting to watch. This new master plan continues that momentum. I am encouraged about what this new phase means for the continued vitality of our great city and the jobs and resources it will bring to our community.”